1481639-85-3Relevant articles and documents
Evaluation of Baylis-Hillman Routes to 3-(Aminomethyl)coumarin Derivatives
Olasupo, Idris,Rose, Nathan R.,Klein, Rosalyn,Adams, Luqman A.,Familoni, Oluwole B.,Kaye, Perry T.
, p. 251 - 258 (2013/12/04)
The relative merits of two different Baylis-Hillman approaches toward the preparation of coumarin derivatives, containing peptide-like side chains, have been explored. In one approach, use of methyl acrylate as the activated alkene requires a protecting group strategy, an approach that is not necessary when using tert-butyl acrylate. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]