1481687-01-7

Basic information

• Product Name: (1E,4E)-1-(4-chlorophenyl)-5-(4-((8-methylquinazolin-4-yl)oxy)phenyl)penta-1,4-dien-3-one
• CAS NO: 1481687-01-7
• Molecular Weight: 426.902
• Mol File: 1481687-01-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1E,4E)-1-(4-chlorophenyl)-5-(4-((8-methylquinazolin-4-yl)oxy)phenyl)penta-1,4-dien-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1E,4E)-1-(4-chlorophenyl)-5-(4-((8-methylquinazolin-4-yl)oxy)phenyl)penta-1,4-dien-3-one(1481687-01-7)
• EPA Substance Registry System: (1E,4E)-1-(4-chlorophenyl)-5-(4-((8-methylquinazolin-4-yl)oxy)phenyl)penta-1,4-dien-3-one(1481687-01-7)

Safety Data

• Hazardous Substances Data: 1481687-01-7(Hazardous Substances Data)

Upstream product

• 19181-54-5 8-methylquinazolin-4(3H)-one 
• 58421-80-0 4-chloro-8-methylquinazoline 
• 123-08-0 4-hydroxy-benzaldehyde 
• 22214-30-8 (E)-4-(4-hydroxyphenyl)-3-buten-2-one 
• 1442476-86-9 (E)-4-(4-((8-methylquinazolin-4-yl)oxy)phenyl)but-3-en-2-one 
• 104-88-1 4-chlorobenzaldehyde 
• 4389-45-1 3-methylantranilic acid 

Relevant articles and documents

Synthesis and antitumor properties of novel curcumin analogs

A series of novel curcumin (CC) analogs were synthesized by reacting substituted aldehydes with inter-mediates 4a and 4b. The inhibitory activities of these CC analogs were investigated on human cancer cells PC3, Bcap-37, and MGC-803 in vitro by MTT assay. The results showed that most of the title compounds displayed moderate to high levels of antitumor activities. Compound 5f, the most active CC analogs, has the IC50 values of 1.34 ± 0.28, 3.90 ± 0.36, and 0.86 ± 0.44 μM against the three human cancer cells assayed, respectively. Furthermore, subsequent fluorescence staining and flow cytometry analysis indicated compound 5f could induce apoptosis in PC3, Bcap-37, and MGC-803 cells, and the apoptosis ratio reachs the peak (27.1%) in MGC-803 cells at 24 h after treatment at 10 μM. Springer Science+Business Media 2013.