1482-98-0

Basic information

• Product Name: L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO
• Synonyms: L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO;(2S)-2,4-diaminobutanoicacidhydrochloride;(s)-(+)-2,4-diaminobutanoicacidhydrochloride;Butanoic acid, 2,4-diaMino-, Monohydrochloride, (S)-;L-alpha,gamma-Diaminobutyric acid monohydrochloride;(S)-2,4-Diaminobutanoic acid monohydrochloride
• CAS NO: 1482-98-0
• Molecular Formula: C₄H₁₂N₂O₂*2Cl
• Molecular Weight: 154.59534
• Product Categories: DAB (2,4-Diaminobutyric Acid);A - HPeptide Synthesis;Amino Acids;Modified Amino Acids;Unnatural Amino Acid Derivatives
• Mol File: 1482-98-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 193 °C (dec.)(lit.)
• Boiling Point: 334.6°Cat760mmHg
• Flash Point: 156.2°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 2.4E-05mmHg at 25°C
• BRN: 6086583
• CAS DataBase Reference: L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO(CAS DataBase Reference)
• NIST Chemistry Reference: L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO(1482-98-0)
• EPA Substance Registry System: L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO(1482-98-0)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-36/39
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 1482-98-0(Hazardous Substances Data)

Usage

General Description

L-2 4-Diaminobutyric acid monohydrochloride is a chemical compound that is commonly used in biochemical research and drug development. It is classified as a diamine, containing two amino groups, and is a derivative of the amino acid lysine. L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO has been found to have various biological activities, including antimicrobial and antitumor properties, and has been studied for its potential therapeutic applications in cancer and neurodegenerative diseases. L-2 4-Diaminobutyric acid monohydrochloride may also serve as a building block for the synthesis of peptide-based drugs and is used as a reagent in chemical and biochemical assays.

InChI:InChI=1/C4H10N2O2.ClH/c5-2-1-3(6)4(7)8;/h3H,1-2,5-6H2,(H,7,8);1H/t3-;/m0./s1

Upstream product

• 1190-46-1 N-γ-acetyl-L-2,4-diaminobutyrate 
• 73143-97-2 (S)-2,4-diamino-butyric acid ; hydrobromide 
• 103668-08-2 (R)-2,4-Diamino-butyric acid ethyl ester; hydrochloride 
• 34404-27-8 N^α,N^γ-bis(t-butoxycarbonyl)-L-α,γ-butyric acid 
• 127531-09-3 (S)-3-Cyano-2-[(1R,2R,5R)-2-hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-propionic acid ethyl ester 

Downstream Products

• 1217645-10-7 (R)-2,4-bis((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid 
• 55478-23-4 (S)-2,4-bis(((benzyloxy)carbonyl)amino)butanoic acid 
• 34404-27-8 N^α,N^γ-bis(t-butoxycarbonyl)-L-α,γ-butyric acid 
• 4128-00-1 (3S)-3-aminopyrrolidin-2-one 
• 25139-87-1 ⁽⁵⁾-(+)(D)-N,N'-Ditosyl-2,4-diamino-butanol 
• 126581-98-4 DPAB-L-DBA (trans) 
• 117106-22-6 (S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-aminobutanoic acid 
• 97347-23-4 N^α,N^γ-diBoc-L-2,4-diaminobutyric acid p-nitrobenzyl ester 
• 2130-77-0 (S)-2-Amino-4-benzyloxycarbonylamino-butyric acid 

Relevant articles and documents

SYNTHESIS OF CYCLIC AMIDINES

The invention relates to an innovative method for synthesis of cyclic amidines. The synthesis starts from a β-, γ- or δ-lactone which is twofold brominated. After esterification of the carboxyl function, the bromine atoms are nucleophilically substituted and the corresponding diamino compound is obtained. The ring closure to the cyclic amidine is accomplished subsequently by reaction with orthoester, imidate or thioimidate. Owing to interposing additional steps for recovery of the diamino compound in enantiomerically pure form, the enantiomers of the cyclic amidines can be stereoselectively synthesized.

The synthesis of unusual tetrahydropyrimidine amino acids

The synthesis of derivatives of 2-(1-an-aminoalkyl)-4-carboxy-3,4,5,6-tetrahydropyrimidines, unusual amino acids isolated from bacterial siderophores, is described, from condensation of N-protected amino acids imidates or thiomidates with 2,4-diaminobutyrylglycine methyl ester.