148215-62-7

Basic information

• Product Name: 2-(2-nitrophenyl)-1H-imidazo<4,5-b>pyridine
• Synonyms: 2-(2-nitrophenyl)-1H-imidazo<4,5-b>pyridine
• CAS NO: 148215-62-7
• Molecular Weight: 240.221
• Mol File: 148215-62-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2-nitrophenyl)-1H-imidazo<4,5-b>pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-nitrophenyl)-1H-imidazo<4,5-b>pyridine(148215-62-7)
• EPA Substance Registry System: 2-(2-nitrophenyl)-1H-imidazo<4,5-b>pyridine(148215-62-7)

Safety Data

• Hazardous Substances Data: 148215-62-7(Hazardous Substances Data)

Upstream product

• 452-58-4 2,3-Diaminopyridine 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 925438-59-1 C₁₈H₂₂N₄O₃Si 
• 925438-57-9 C₁₈H₂₂N₄O₃Si 
• 951-73-5 2-(2-aminophenyl)-1H-imidazo<4,5-b>pyridine 

Relevant articles and documents

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

SIRT1 is an NAD+-dependent protein deacetylase that appears to produce beneficial effects on metabolic parameters such as glucose and insulin homeostasis. Activation of SIRT1 by resveratrol (1) has been shown to modulate insulin resistance, increase mitochondrial content and prolong survival in lower organisms and in mice on a high fat diet. Herein, we describe the identification and SAR of a series of oxazolo[4,5-b]pyridines as novel small molecule activators of SIRT1 which are structurally unrelated to and more potent than resveratrol.