148223-47-6Relevant articles and documents
Synthesizing method of 6-benzyloxy-7-methoxy-3,4-dihydroisoquinoline
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Paragraph 0069-0077; 0083-0090; 0095-0102, (2019/08/07)
The invention discloses a synthesizing method of 6-benzyloxy-7-methoxy-3,4-dihydroisoquinoline in the field of medicine synthesizing. The synthesizing method includes: dissolving 3-benzyloxy-4- methoxy phenylethylamine or hydrochloride thereof in the mixed liquid of glacial acetic acid and trifluoroacetic acid to generate the 6-benzyloxy-7-methoxy-3,4-dihydroisoquinoline under the effect of hexamethylene tetramine in a closed-loop manner. The synthesizing method has the advantages that the 3-benzyloxy-4- methoxy phenylethylamine is subjected to one-step closed-loop reaction under the effect ofhexamethylene tetramine to prepare the target product, and the synthesizing route is short; the 3-benzyloxy-4- methoxy phenylethylamine and the 6-benzyloxy-7-methoxy-3,4-dihydroisoquinoline are purified in a recrystallization manner to prepare the hydrochloride of the 3-benzyloxy-4- methoxy phenylethylamine and the 6-benzyloxy-7-methoxy-3,4-dihydroisoquinoline, the purification operation is simple, and the obtained compound is stable in property and can be conveniently stored for a long time.