148237-82-5Relevant academic research and scientific papers
4-hydroxy-2-quinolones 165*. 1-R-4-hydroxy-2-oxo-1,2-dihydro- quinoline-3-carbaldehydes and their thiosemicarbazones. Synthesis, structure, and biological properties
Ukrainets,Yangyang, Liu,Tkach,Gorokhova,Turov
scheme or table, p. 705 - 714 (2010/04/02)
Two variants are discussed of the synthesis of 1-R-4-hydroxy-2-oxo-1,2- dihydroquinoline-3-carboxylic acid β-N-tosylhydrazides which undergo a McFayden-Stevens reaction to give 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3- carbaldehydes in high yields. It was shown that the thiosemicarbazones prepared from them exist in the solid state exclusively in the syn-form while in solution a hydrazone ? enhydrazine tautomerism is observed. The results of a study of the antitubercular activity of the synthesized compounds are reported.
4-HYDROXYQUINOLONES-2. 5. SYNTHESIS AND PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES OF NEW PYRAZOLE DERIVATIVES
Ukrainets, I. V.,Bezuglyi, P. A.,Treskach, V. I.,Kornilov, M. Yu.,Turov, A. V.,et al.
, p. 912 - 916 (2007/10/02)
Hydrazinolysis of 1-R-3-carbethoxy-4-hydroxyquinolones-2 was used to synthesize the corresponding hydrazides; thermal cyclodehydration of the latter yielded 3-oxopyrazolo--5-R-quinolones-4.Findings relating to their analgesic and antiphlogistic activity are outlined.
