148257-06-1Relevant articles and documents
Synthesis of novel racemic carbocyclic nucleosides derived from 5,6-disubstituted norbornene
Sala, Michal,Hebabecky, Hubert,Draeinsky, Martin,Masojidkova, Milena,De Palma, Armando M.,Neyts, Johan,Holy, Antonin
, p. 1 - 20 (2010)
Novel class of the carbocyclic nucleosides based on bicyclo[2.2.1]heptene/ heptane was prepared by two approaches. Thymine analogues were synthesized starting from methyl (1R,4S)-bicyclo[2.2.1]hepta-2,5-diene-2-carboxylate 1 by Michael addition of the thy
Mediators of hedgehog signaling pathways, compositions and uses related thereto
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Page/Page column 77; 78, (2015/11/27)
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.
Backbone regulation mimicry by β-peptidic foldamers: formation of a 10-helix in a mixed 6-strand/14-helix conformational pool
Jagadeesh, Bharatam,Kiran, Marelli Udaya,Sudhakar, Ambadi,Chandrasekhar, Srivari
scheme or table, p. 12592 - 12595 (2010/06/21)
A highly robust 6-strand transforms into a right-handed 10-helix through the substitution of 14-helical nucleating residues at alternate positions along the backbone of the oligomer has been reported. The heterooligomers, tetramer and hexamer with NAA and
