148304-10-3

Upstream product

• 89019-07-8 7-methoxy-8-coumarinul methyl ketone 
• 2747-05-9 4-methylumbelliferyl acetate 
• 108-46-3 recorcinol 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 116589-49-2 8-[(E)-3-(3,4-Dimethoxy-phenyl)-acryloyl]-7-methoxy-4-methyl-chromen-2-one 
• 2555-29-5 8-acetyl-7-hydroxy-4-methyl-2H-chromen-2-one 

Downstream Products

• 351501-22-9 8-[8-chloro-2-(3,4-dimethoxy-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepin-4-yl]-7-hydroxy-4-methyl-chromen-2-one 

Relevant academic research and scientific papers

Microwave-assisted synthesis of substituted 4-chloro-8-methyl-2-phenyl-1,5-dioxa-2H-phenanthren-6-ones and their antimicrobial activity

Chromene and coumarin scaffolds are known for their potential antimicrobial activity. Herein, we have synthesized hybrid compounds containing both, substituted 4-chloro-8-methyl-2-phenyl-1,5-dioxa-2H-phenanthren-6-ones, 3a-o have been synthesized from sub

Microwave-assisted synthesis of (E)-7-[(1-benzyl-1H-1,2,3-triazol-4-yl)methoxy]-8-(3-arylacryloyl)-4-methyl-2H-chromen-2-ones and their antimicrobial activity

Hybrid compounds are relevant products in the structure-activity relationships analysis. A new series of hybrid compounds containing coumarin, 1,2,3-triazole, and chalcone substructures were synthesized and screened for their antimicrobial activity. The s

Synthesis and antiproliferative and c-Src kinase inhibitory activities of cinnamoyl-and pyranochromen-2-one derivatives

A series of 6-and 8-cinnamoylchromen-2-one and dihydropyranochromen-2-one derivatives were synthesized and their antiproliferative activities were evaluated against three human cancer cell lines, i.e., ovarian adenocarcinoma (SK-OV-3), leukemia (CCRF-CEM), and breast carcinoma (MCF-7). In general, 8-cinnamoylchromen-2-one derivatives were found to have higher antiproliferative activity against the cancer cells when compared with 6-cinnamoyl analogues. Among all of the hybrid chromen-2-one-chalcone/flavanone compounds, a 7-hydroxy-8-cinnamoylchromen-2-one derivative 35 was found to be consistently active against all the cancer cell lines and inhibited the cell proliferation of SK-OV-3, CCRF-CEM, and MCF-7 by 63%, 50%, and 43%, respectively, at a concentration of 50 μmol/L after 72 h of incubation. This compound also exhibited the highest Src kinase inhibition (IC50 = 14.5 μmol/L). Structure-activity relationship studies provided insights for designing the next generation of chromen-2-one-chalcone hybrid prototypes and the development of new leads as anticancer agents and (or) Src kinase inhibitors.

Synthesis of some new 1,5-benzothiazepines containing 2H-1-benzopyran-2-one heterocycle

A facile procedure has been developed for the synthesis of 2-aryl/heteryl-4-(2H-1-benzopyran-2-one-8-yl)-2,3-dihydro-1,5-benzothiazepines (5a-o) by the reaction of 1-(2H-1-benzopyran-2-one-8-yl)-3-aryl/heteryl-2-propenones (3a-k) with 2-aminothiophenols (4a,b) in toluene in the presence of triflouroacetic acid.

Synthesis of new α-pyronochalcones and related cyclisation products

Ten substituted α-pyronochalcones (I-X) and four α-pyronoflavanones (XI-XIV) have been obtained from 8-acetyl-7-hydroxy-4-methylcoumrin and characterised.The present data cast serious doubts in the claim in a recent publication on the synthesis of benzopy

New Route to Synthesis of Some 8-(Dihydrocinnamoyl)dihydrocumarin Derivatives

The synthesis of 8-dihydrocinnamoyldihydrocoumarin derivatives starting from 8-acetyl-7-methoxy substituted coumarins involves: (i) aldol condensation with substituted benzaldehydes; (ii) partial demethylation of condensation products (AlCl3/acetonitrile)