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148334-80-9

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148334-80-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 148334-80-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,3,3 and 4 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 148334-80:
(8*1)+(7*4)+(6*8)+(5*3)+(4*3)+(3*4)+(2*8)+(1*0)=139
139 % 10 = 9
So 148334-80-9 is a valid CAS Registry Number.

148334-80-9Downstream Products

148334-80-9Relevant articles and documents

Potent dipeptidylketone inhibitors of the cysteine protease cathepsin K

Marquis, Robert W.,Ru, Yu,Yamashita, Dennis S.,Oh, Hye-Ja,Yen, Jack,Thompson, Scott K.,Carr, Thomas J.,Levy, Mark A.,Tomaszek, Thaddeus A.,Ijames, Carl F.,Smith, Ward W.,Zhao, Baoguang,Janson, Cheryl A.,Abdel-Meguid, Sherin S.,D'Alessio, Karla J.,McQueney,Veber, Daniel F.

, p. 581 - 588 (1999)

Cathepsin K (EC 3.4.22.38) is a cysteine protease of the papain superfamily which is selectively expressed within the osteoclast. Several lines of evidence have pointed to the fact that this protease may play an important role in the degradation of the bone matrix. Potent and selective inhibitors of cathepsin K could be important therapeutic agents for the control of excessive bone resorption. Recently a series of peptide aldehydes have been shown to be potent inhibitors of cathepsin K. In an effort to design more selective and metabolically stable inhibitors of cathepsin K, a series of electronically attenuated alkoxymethylketones and thiomethylketones inhibitors have been synthesized. The X-ray co-crystal structure of one of these analogues in complex with cathepsin K shows the inhibitor binding in the primed side of the enzyme active site with a covalent interaction between the active site cysteine 25 and the carbonyl carbon of the inhibitor. Copyright (C) 1999 Elsevier Science Ltd.

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