148372-20-7Relevant articles and documents
Synthesis of (-)-Pinidine via Asymmetric, Electrophilic Enolate Hydroxyamination/Nitrone Reduction
Oppolzer, Wolfgang,Merifield, Eric
, p. 957 - 962 (2007/10/02)
Enantiomerically pure (-)-pinidine (1) has been synthesized in 18.5 percent overall yield by a nine-step sequence starting from keto-ester 2.The key step 5 -> 6 involves an asymmetric, electrophilic enolate hydroxyamination.Diastereoselective hydrogenatio