148372-95-6

Basic information

• Product Name: 3-(1-(ethylamino)ethylidene)-6-methyl-3H-pyran-2,4-dione
• Synonyms: 3-(1-(ethylamino)ethylidene)-6-methyl-3H-pyran-2,4-dione
• CAS NO: 148372-95-6
• Molecular Formula: C10H13 N O3
• Molecular Weight: 195.22
• Mol File: 148372-95-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 338.3°Cat760mmHg
• Flash Point: 158.4°C
• Appearance: /
• Density: 1.155g/cm³
• Vapor Pressure: 9.91E-05mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: 3-(1-(ethylamino)ethylidene)-6-methyl-3H-pyran-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-(ethylamino)ethylidene)-6-methyl-3H-pyran-2,4-dione(148372-95-6)
• EPA Substance Registry System: 3-(1-(ethylamino)ethylidene)-6-methyl-3H-pyran-2,4-dione(148372-95-6)

Safety Data

• Hazardous Substances Data: 148372-95-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H13NO3/c1-4-11-7(3)9-8(12)5-6(2)14-10(9)13/h5,11H,4H2,1-3H3/b9-7+

Upstream product

• 771-03-9 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one 
• 75-04-7 ethylamine 
• 3265-58-5 2,6-dimethyl-4-oxopyran-3-carboxylic acid 
• 154910-83-5 benzyl 2,6-dimethyl-4-oxopyran-3-carboxylate 
• 23066-91-3 2,6-Dimethyl-4-oxo-4H-pyran-3-carbonsaeure-ethylester 

Relevant articles and documents

Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid

Dehydroacetic acid is a common pyrone derivative used commercially as an antibacterial and antifungal agent. Based on the synthesis of dehydroacetic acid (1) from N-hydroxysuccinimdyl acetoacetate, a novel series of enamine-based derivatives were synthesised in order to improve the antibacterial activity of dehydroacetic acid. The antibacterial activities of the synthesised analogues were evaluated against Escherichia coli and Staphylococcus aureus. Derivative 4d (N-Ph) was identified as the most potent inhibitor of S. aureus growth. Overall, derivative 4b (N-Me) showed the best broad-spectrum activity with five-fold greater minimum inhibitory concentration and 11-fold greater minimum biocidal concentration against E. coli when compared to dehydroacetic acid, in addition to improved antibacterial activity against S. aureus.