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DOTMA(M-160), also known as N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride, is a cationic lipid compound widely used in the formulation of liposomal and lipid-based drug delivery systems. It is recognized for its ability to efficiently encapsulate and deliver nucleic acids, proteins, and other therapeutic agents to target cells. DOTMA(M-160) forms stable and positively charged liposomes, which can interact with negatively charged cell membranes, facilitating the uptake and intracellular delivery of the encapsulated cargo. This makes it a promising tool for gene therapy, vaccination, and targeted drug delivery applications. Additionally, DOTMA(M-160) has also been used in the development of novel lipid-based formulations for improving the stability, bioavailability, and delivery of various pharmaceutical compounds.

148408-89-3

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148408-89-3 Usage

Uses

Used in Pharmaceutical Industry:
DOTMA(M-160) is used as a component in drug delivery systems for its ability to encapsulate and deliver nucleic acids, proteins, and other therapeutic agents to target cells, enhancing the efficiency and effectiveness of drug administration.
Used in Gene Therapy Applications:
DOTMA(M-160) is used as a carrier for nucleic acids in gene therapy for its capacity to facilitate the uptake and intracellular delivery of genetic material, potentially treating genetic disorders and diseases.
Used in Vaccination Development:
DOTMA(M-160) is used as an adjuvant in the development of vaccines to enhance the body's immune response, improving the effectiveness of vaccination.
Used in Targeted Drug Delivery:
DOTMA(M-160) is used as a targeting agent for targeted drug delivery to ensure that therapeutic agents reach specific cells or tissues, reducing side effects and increasing treatment efficacy.
Used in Liposomal Formulation Development:
DOTMA(M-160) is used as a key ingredient in the formulation of liposomal systems to improve the stability, bioavailability, and delivery of pharmaceutical compounds, ensuring better therapeutic outcomes.

Check Digit Verification of cas no

The CAS Registry Mumber 148408-89-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,4,0 and 8 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 148408-89:
(8*1)+(7*4)+(6*8)+(5*4)+(4*0)+(3*8)+(2*8)+(1*9)=153
153 % 10 = 3
So 148408-89-3 is a valid CAS Registry Number.

148408-89-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(2-propionic acid)

1.2 Other means of identification

Product number -
Other names DOTMA

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:148408-89-3 SDS

148408-89-3Upstream product

148408-89-3Downstream Products

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