148440-81-7

Basic information

• Product Name: thioperamide maleate salt
• Synonyms: MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-, (2Z)-2-butenedioate (1:1)
• CAS NO: 148440-81-7
• Molecular Formula: C15H24N4SC4H4O4
• Molecular Weight: 0
• Mol File: 148440-81-7.mol
• Article Data: 0

Chemical Properties

• Appearance: white/
• Storage Temp.: desiccated under inert gas
• Solubility: H2O: >10mg/mL
• CAS DataBase Reference: thioperamide maleate salt(CAS DataBase Reference)
• NIST Chemistry Reference: thioperamide maleate salt(148440-81-7)
• EPA Substance Registry System: thioperamide maleate salt(148440-81-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 148440-81-7(Hazardous Substances Data)

Usage

Description

Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg. At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid.

Uses

Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.

Biochem/physiol Actions

Thioperamide is a potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.