1484459-62-2

Upstream product

• 1780-26-3 2,4-dichloro-2-methylpyrimidine 
• 1194-22-5 2-methyl-4,6-dihydroxypyrimidine 
• 330992-27-3 4-methoxybenzaldehyde (6-chloro-2-methylpyrimidin-4-yl)hydrazone 
• 52476-88-7 1-(6-chloro-2-methyl-pyrimidin-4-yl)hydrazine 

Downstream Products

• 1598384-00-9 7-chloro-2-(2-methoxyphenyl)-5-methyl-[1,2,4]triazolo[1,5-c]pyrimidine 

Relevant academic research and scientific papers

IBD-mediated oxidative cyclization of pyrimidinylhydrazones and concurrent Dimroth rearrangement: Synthesis of [1,2,4]triazolo[1,5-c]pyrimidine derivatives

Oxidative cyclization of 6-chloro-4-pyrimidinylhydrazones 4 with iodobenzene diacetate (IBD) in dichloromethane gives rise to [1,2,4]triazolo[4,3-c]pyrimidine derivatives 5a-o. These incipient products undergo feasible Dimroth rearrangement to furnish the isolated [1,2,4]triazolo[1,5-c]pyrimidines 6a-o in moderate to high yields.