14847-86-0Relevant academic research and scientific papers
Preparation of quinolinium salts differing in the length of the alkyl side chain
Marek, Jan,Buchta, Vladimir,Soukup, Ondrej,Stodulka, Petr,Cabal, Jiri,Ghosh, Kallol K.,Musilek, Kamil,Kuca, Kamil
, p. 6386 - 6394 (2012)
Quaternary quinolinium salts differing in alkyl chain length are members of a widespread group of cationic surfactants. These compounds have numerous applications in various branches of industry and research. In this work, the preparation of quinoline-derived cationic surface active agents differing in the length of the side alkyl chains (from C8 to C20) is described. An HPLC method was successfully developed for distinction of all members of the series of prepared long-chain quinolinium derivatives. In conclusion, some possibilities of intended tests or usage have been summarized. In vitro testing using a microdilution broth method showed good activity of a substance with a C12 chain length against Gram-positive cocci and Candida species.
Antimicrobial and antibiofilm activities of 1-alkylquinolinium bromide ionic liquids
Busetti, Alessandro,Crawford, Deborah E.,Earle, Martyn J.,Gilea, Manuela A.,Gilmore, Brendan F.,Gorman, Sean P.,Laverty, Garry,Lowry, Andrew F.,McLaughlin, Martin,Seddon, Kenneth R.
experimental part, p. 420 - 425 (2010/08/04)
Quinoline derivatives are known to possess a range of bioactive and medicinal activities, which have been exploited in the design of antibacterial, antifungal and antimalarial compounds. In this study, we report on the microbiological toxicity of a series of 1-alkylquinolinium bromides against a range of clinically relevant microorganisms, in both planktonic and sessile (biofilm) cultures. A comparison of antimicrobial activity against planktonic bacteria and established biofilms is presented. In general, 1-alkylquinolinium ionic liquids possess excellent, broad spectrum antimicrobial activity against microorganisms grown in both the planktonic and sessile, or biofilm, mode of growth. Importantly, these compounds are potent against Gram positive and Gram negative bacteria, as well as fungi, with a clear dependency on length of the alkyl substituent for activity, with compounds containing twelve and fourteen carbons in the alkyl group exhibiting highest antimicrobial and antibiofilm activity.
