148529-77-5Relevant academic research and scientific papers
Preparation of peptide thioacids using the Kaiser oxime resin
Schwabacher,Maynard
, p. 1269 - 1270 (1993)
Peptide C-terminal thioacids are readily prepared with protecting groups intact by cleavage of peptides from Kaiser's oxime ester resin by treatment with hexamethyldisilathiane/tetrabutylammonium fluoride. Such thioacids are useful for peptide fragment co
α-Methylphenacyl thioesters as convenient thioacid precursors
Hatanaka, Toru,Yuki, Ryosuke,Saito, Ryota,Sasaki, Kaname
supporting information, p. 10589 - 10592 (2016/11/30)
α-Methylphenacyl (Mpa) thioesters are described as precursors of thioacids. Mpa thioesters are accessible via the condensation of carboxylic acids and phenacyl thiol, which is easily prepared without column chromatography. The Mpa thioesters are selectively deprotected by reduction with zinc dust in the presence of conventional thioacid protecting groups. In addition, the Mpa group exhibits orthogonal reactivity to the Boc group. These features are expected to facilitate the preparation of complex thioacids, including those in peptides.
An alternate preparation of thioester resin linkers for solid-phase synthesis of peptide C-terminal thioacids
Goldstein, Alex S.,Gelb, Michael H.
, p. 2797 - 2800 (2007/10/03)
An alternative preparation of thioester resin linkers for solid-phase synthesis of peptide C-terminal thioacids is presented. (C) 2000 Elsevier Science Ltd.
