148554-93-2

Upstream product

• 139374-78-0 (4S,5R)-N-(((tert)-butyloxy)carbonyl)-5-(cyclohexylmethyl)-4-hydroxy-2-pyrrolidinone 
• 4111-54-0 lithium diisopropyl amide 
• 148472-62-2 (5R)-N-(((tert)-butyloxy)carbonyl)-5-(cyclohexylmethyl)-2,4-pyrrolidindione 
• 37736-82-6 (S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid 

Downstream Products

• 148472-65-5 (2R,3S,4R)-4-(N-(((tert)-butyloxy)carbonyl)-amino)-2-benzyl-5-cyclohexyl-3-hydroxy-pentanoic acid acetonide 
• 148472-68-8 (2R,3S,4R)-4-(N-(((tert)-butyloxy)carbonyl)-amino)-2-(N-((benzyloxy)carbonyl)-amino)-5-cyclohexyl-3-hydroxy-1-phenylpentane acetonide 
• 148472-71-3 (2R,3S,4R)-4-(N-(((tert)-butyloxy)carbonyl)-amino)-2-amino-5-cyclohexyl-3-hydroxy-1-phenylpentane acetonide 

Relevant academic research and scientific papers

A diastereoselective synthesis of pseudo-C2 -symmetric 1,3-diamino-2-propanols as core units in HIV protease inhibitors

Inhibitors of HIV-1 protease are effective against the proliferation of HIV-1 infection in vitro. Based on the inherent symmetry of the protease homodimer, C2-symmetric and pseudo-C2-symmetric inhibitors have been designed, synthesiz