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148579-57-1

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148579-57-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 148579-57-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,5,7 and 9 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 148579-57:
(8*1)+(7*4)+(6*8)+(5*5)+(4*7)+(3*9)+(2*5)+(1*7)=181
181 % 10 = 1
So 148579-57-1 is a valid CAS Registry Number.

148579-57-1Relevant articles and documents

PYRROLOBENZODIAZEPINE DIMER PRECURSOR AND LIGAND-LINKER CONJUGATE COMPOUND THEREOF

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, (2020/02/18)

The present invention relates to a pyrrolobenzodiazepine dimer prodrug and a ligand-linker conjugate compound thereof, a composition containing these, and therapeutic use thereof particularly as an anticancer drug. The stability of the compounds themselves and the stability thereof in plasma are excellent and the compounds are advantageous in terms of manifestation of toxicity, and thus the compounds are industrially useful in that it is possible to target proliferative diseases such as cancer, to perform a specific treatment, to maximize the drug efficacy, and to minimize the occurrence of side effects.

Extended scaffold glucuronides: En route to the universal synthesis of O -aryl glucuronide prodrugs

Walther, Raoul,Jarlstad Olesen, Morten T.,Zelikin, Alexander N.

, p. 6970 - 6974 (2019/08/01)

We demonstrate that an extended scaffold based on a self-immolative linker (SIL) enables the universal production of O-aryl glucuronide prodrugs: high yield glucuronidation is performed on a precursor substrate (SIL) and the subsequent drug conjugation proceeds via less challenging chemical reactions.

CALICHEAMICIN DERIVATIVES AND ANTIBODY DRUG CONJUGATES THEREOF

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, (2018/08/20)

The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.

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