148581-34-4

Upstream product

• 120-72-9 indole 
• 148581-33-3 4-[(S)-1-(4-Isobutyl-phenyl)-ethoxy]-benzoyl chloride 
• 148581-32-2 4-[(S)-1-(4-Isobutyl-phenyl)-ethoxy]-benzoic acid 
• 150300-58-6 4-[1-(4-Isobutyl-phenyl)-ethoxy]-benzoic acid 
• 150300-57-5 4-[1-(4-Isobutyl-phenyl)-ethoxy]-benzoic acid ethyl ester 
• 59771-01-6 1-(para-isobutyl phenyl)-1-bromoethane 
• 120-47-8 Ethyl 4-hydroxybenzoate 

Downstream Products

• 148366-88-5 ethyl (S)-4-[3-[4-[[1-(4-isobutylphenyl)ethyl]oxy]benzoyl]-1H-indol-1-yl]butyrate 

Relevant academic research and scientific papers

The development of non-steroidal dual inhibitors of both human 5α- reductase isozymes

The design, synthesis and biological properties of homochiral non- steroidal inhibitors of both isozymes of human 5α-reductase are described. The o-hydroxy aniline moiety of the initial lead (1) can be replaced by a 3- acyl indole isostere, whilst the minimum energy conformation of the benzyl ether in the potent inhibitor (3) is mimicked by the conformationally locked benzodioxolane system in the potent non-steroidal inhibitor (7). Pharmacokinetics and oral efficacy in a rat model of BPH are presented for (3) and (7).