148589-13-3Relevant articles and documents
Dehydrogenative Heck coupling of biologically relevant N-heteroarenes with alkenes: Discovery of fluorescent core frameworks
Huang, Yumin,Song, Feijie,Wang, Zhen,Xi, Peihua,Wu, Ningjie,Wang, Zhigang,Lan, Jingbo,You, Jingsong
supporting information; experimental part, p. 2864 - 2866 (2012/04/17)
A Pd/Cu-catalyzed dehydrogenative Heck coupling is established that allows direct alkenylation of various biologically relevant N-heteroarenes with alkenes. The resulting π-extended alkenylated N-heteroarenes exhibit interesting fluorescent properties and have proven to be potentially useful fluorescent probes for bioimaging. The Royal Society of Chemistry 2012.
(E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine, a caffeine derivative acting both as antagonist of adenosine A2A receptors and as inhibitor of MAO-B
Frederick, Raphael,Ooms, Frederic,Castagnoli Jr., Neal,Petzer, Jacques P.,Feng, Jiang-Fan,Schwarzschild, Michael A.,Van Der Schyf, Cornells J.,Wouters, Johan
, p. o531-o532 (2007/10/03)
In the crystal structure of (E)-8-(3-chlorostyryl)-1,3,7- trimethylxanthine (CSC) [systematic name: (E)-8-(3-chlorostyryl)-1,3,7-trimethyl-3,7-dihydro-1H- purine-2,6-dione], C16H15ClN4O2, the xanthine ring and the lateral styryl chain are coplanar. The crystal packing involves mainly parallel stacking of these planar molecules. The electrostatic potential calculated on the crystal structure conformation confirms the pharmacophore elements associated with MAO-B inhibition.
Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists
Jacobson,Gallo-Rodriguez,Melman,Fischer,Maillard,Van Bergen,Van Galen,Karton
, p. 1333 - 1342 (2007/10/02)
A series of substituted 8-styryl derivatives of 1,3,7-alkylxanthines was synthesized as potential A2-selective adenosine receptor antagonists, and the potency at rat brain A1- and A2-receptors was studied in radioligand bi
