1486-51-7Relevant articles and documents
Preparation and mesomorphic properties of highly fluorinated materials incorporating S-ethyl-lactate
De Givenchy, Elisabeth Taffin,Guittard, Frederic,Geribaldi, Serge
, p. 91 - 98 (2001)
The synthesis of three different chiral short molecular weight compounds have been reported. The overall compounds incorporate a linear perfluorinated tail and S-ethyl-Iactate as chiral moiety. Each compound differ to the other by one molecular parameter: a spacer carbonyloxy or oxycarbonylmethoxy or by the presence or not of an ester function between the two aromatic rings of the mesogenic core. The synthesis have been carried out from 2-F-hexylethyliodide or 2-F-hexylethanol. The mesomorphic properties have been characterized by light microscopy and by differential thermal analysis showing the peculiar effect of the spacer. The two biphenyl derivatives exhibit liquid crystal properties over a wide temperature range. The mesophase for both compounds is smectic of type A. However, the introduction of an ester function in the core contribute to enhance the melting temperature and suppress the liquid crystal behavior.
Multichiral liquid crystals based on terphenyl core laterally substituted by chlorine atom
Cigl, Martin,Hamplová, Věra,Novotná, Vladimíra,Pociecha, Damian,Podoliak, Natalia
, (2021/05/17)
We designed a new type of antiferroelectric liquid crystalline structure with versatile properties. For this purpose, we modified the previously studied liquid crystalline compounds based on terphenyl molecular core laterally substituted with a chlorine atom. Two lactate units were attached to the chiral chain with the aim to support antiferroelectric structures. We studied the mesomorphic properties of new compounds by means of texture observations under a polarised light microscope, by dielectric spectroscopy and electro-optical measurements. To confirm the phase identification, x-ray measurements were performed. We found that the studied compounds revealed a SmA*-SmC* phase sequence in a broad temperature range. We proved an antiferroelectric phase with orthoconic properties for selected structural modifications. Such valuable optical properties with the tilt angle about 45° promise a big potential for applications.
Discovery of benzamide-hydroxypyridinone hybrids as potent multi-targeting agents for the treatment of Alzheimer's disease
Bai, Renren,Gu, Jinping,Guo, Jianan,Jiang, Xiaoying,Xie, Yuanyuan,Zhang, Changjun,Zhou, Tao
, p. 2045 - 2054 (2021/10/08)
A novel class of benzamide-hydroxypyridinone (HPO) derivatives were innovatively designed, synthesised, and biologically evaluated as potential multitargeting candidates for the treatment of Alzheimer's disease (AD) through pharmacophores-merged approaches based on lead compounds 18d, benzyloxy phenyl analogs, and deferiprone (DFP). These hybrids possessed potent Monoamine oxidase B (MAO-B) inhibition as well as excellent iron chelation, with pFe3+ values ranging from 18.13 to 19.39. Among all the compounds, 8g exhibited the most potent selective MAO-B inhibitor (IC50 = 68.4 nM, SI = 213). Moreover, 8g showed favourable pharmacokinetic properties and had great potential to penetrate the BBB in silico and PAMPA-BBB assay. Molecular modelling showed that 8g could adopt an extended conformation and have more enhanced interactions with MAO-B than 18d. In vitro and in vivo assays demonstrated that 8g remarkably resisted Aβ-induced oxidation and ameliorated cognitive impairment induced by scopolamine. Taken collectively, these results suggest that compound 8g is a potential multifunctional candidate for anti-AD treatment.
