148642-42-6 Usage
Description
GR127935 is an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1B, 5-HT1Dα, and 5-HT1Dβ (IC50s = 3.16, 1.26, and 0.13 nM, respectively). It is selective for the 5-HT1B and 5-HT1D receptors over other 5-HT receptors (IC50s = 39.81->10,000 nM in radioligand binding assays). GR127935 increases extracellular 5-HT levels in the guinea pig frontal cortex and prevents increases in 5-HT in rat frontal cortex induced by the selective serotonin reuptake inhibitor paroxetine . It enhances memory consolidation in an autoshaping learning task in rats when administered post-training at a dose of 10 mg/kg. It has been used to elucidate the 5-HT receptor subtypes involved in the anti-inflammatory activity of sumatriptan following myocardial ischemia-reperfusion injury and testicular torsion/detorsion.
Uses
GR 127935 Hydrochloride is a selective and potent 5-HT1B/1D serotonin receptor antagonist.
Biochem/physiol Actions
Potent, selective and orally active 5-HT1B/1D serotonin receptor antagonist.
Check Digit Verification of cas no
The CAS Registry Mumber 148642-42-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,6,4 and 2 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 148642-42:
(8*1)+(7*4)+(6*8)+(5*6)+(4*4)+(3*2)+(2*4)+(1*2)=146
146 % 10 = 6
So 148642-42-6 is a valid CAS Registry Number.