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148642-42-6

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  • N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride

    Cas No: 148642-42-6

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148642-42-6 Usage

Description

GR127935 is an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1B, 5-HT1Dα, and 5-HT1Dβ (IC50s = 3.16, 1.26, and 0.13 nM, respectively). It is selective for the 5-HT1B and 5-HT1D receptors over other 5-HT receptors (IC50s = 39.81->10,000 nM in radioligand binding assays). GR127935 increases extracellular 5-HT levels in the guinea pig frontal cortex and prevents increases in 5-HT in rat frontal cortex induced by the selective serotonin reuptake inhibitor paroxetine . It enhances memory consolidation in an autoshaping learning task in rats when administered post-training at a dose of 10 mg/kg. It has been used to elucidate the 5-HT receptor subtypes involved in the anti-inflammatory activity of sumatriptan following myocardial ischemia-reperfusion injury and testicular torsion/detorsion.

Uses

GR 127935 Hydrochloride is a selective and potent 5-HT1B/1D serotonin receptor antagonist.

Biochem/physiol Actions

Potent, selective and orally active 5-HT1B/1D serotonin receptor antagonist.

Check Digit Verification of cas no

The CAS Registry Mumber 148642-42-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,6,4 and 2 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 148642-42:
(8*1)+(7*4)+(6*8)+(5*6)+(4*4)+(3*2)+(2*4)+(1*2)=146
146 % 10 = 6
So 148642-42-6 is a valid CAS Registry Number.

148642-42-6 Well-known Company Product Price

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  • Sigma

  • (G5793)  GR 127935 hydrochloride hydrate  >98% (HPLC), powder

  • 148642-42-6

  • G5793-10MG

  • 2,583.36CNY

  • Detail
  • Sigma

  • (G5793)  GR 127935 hydrochloride hydrate  >98% (HPLC), powder

  • 148642-42-6

  • G5793-50MG

  • 10,945.35CNY

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148642-42-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name GR 127935 hydrochloride hydrate

1.2 Other means of identification

Product number -
Other names N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:148642-42-6 SDS

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