148665-49-0 Usage
Description
3'-N''-(3'''-azido-3'''-deoxythymid-3''-yl)-3'-deoxythymidine, also known as Zidovudine USP Related Compound G, is a chemical compound derived from thymidine. It is characterized by the presence of an azido group at the 3''' position, which distinguishes it from other thymidine derivatives. 3'-N''-(3'''-azido-3'''-deoxythymid-3''-yl)-3'-deoxythymidine has gained significant attention due to its potential applications in various fields, particularly in the development of antiviral agents.
Uses
Used in Antiviral Applications:
3'-N''-(3'''-azido-3'''-deoxythymid-3''-yl)-3'-deoxythymidine is used as an antiviral agent for its anti-HIV activity. It has been found to be effective in inhibiting the replication of the Human Immunodeficiency Virus (HIV) by interfering with the viral reverse transcriptase enzyme, thus preventing the formation of viral DNA and subsequent viral replication.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3'-N''-(3'''-azido-3'''-deoxythymid-3''-yl)-3'-deoxythymidine is used as a key intermediate in the synthesis of N-3-substituted thymidine nucleosides. These nucleoside analogs have potential applications as antiviral agents, particularly against HIV. The development of such compounds can lead to the creation of new and more effective treatments for HIV-infected individuals.
Used in Biological Research:
3'-N''-(3'''-azido-3'''-deoxythymid-3''-yl)-3'-deoxythymidine is also utilized in biological studies as a research tool. It can be employed in various experimental setups to investigate the mechanisms of HIV replication, the action of antiviral drugs, and the development of drug resistance. Additionally, this compound can be used to study the interactions between nucleic acids and proteins, as well as to develop new strategies for the design of novel antiviral agents.
Check Digit Verification of cas no
The CAS Registry Mumber 148665-49-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,6,6 and 5 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 148665-49:
(8*1)+(7*4)+(6*8)+(5*6)+(4*6)+(3*5)+(2*4)+(1*9)=170
170 % 10 = 0
So 148665-49-0 is a valid CAS Registry Number.
148665-49-0Relevant articles and documents
Serendipitous discovery of a zidovudine guanidine complex: A superior process for the production of zidovudine
Radatus, Bruno K.
, p. 1281 - 1286 (2011)
A superior process for the commercial production of zidovudine (AZT) has been developed. It was discovered that an AZT-guanidine complex formed when a crude zidovudine solution was treated with guanidine. This readily precipitated from protic solvents resulting in the exclusion of impurities and permitted the development of a superior isolation and purification of AZT.
