148665-49-0 Usage
Uses
Used in Antiviral Applications:
3'-N''-(3'''-azido-3'''-deoxythymid-3''-yl)-3'-deoxythymidine is used as an antiviral agent for its anti-HIV activity. It has been found to be effective in inhibiting the replication of the Human Immunodeficiency Virus (HIV) by interfering with the viral reverse transcriptase enzyme, thus preventing the formation of viral DNA and subsequent viral replication.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3'-N''-(3'''-azido-3'''-deoxythymid-3''-yl)-3'-deoxythymidine is used as a key intermediate in the synthesis of N-3-substituted thymidine nucleosides. These nucleoside analogs have potential applications as antiviral agents, particularly against HIV. The development of such compounds can lead to the creation of new and more effective treatments for HIV-infected individuals.
Used in Biological Research:
3'-N''-(3'''-azido-3'''-deoxythymid-3''-yl)-3'-deoxythymidine is also utilized in biological studies as a research tool. It can be employed in various experimental setups to investigate the mechanisms of HIV replication, the action of antiviral drugs, and the development of drug resistance. Additionally, 3'-N''-(3'''-azido-3'''-deoxythymid-3''-yl)-3'-deoxythymidine can be used to study the interactions between nucleic acids and proteins, as well as to develop new strategies for the design of novel antiviral agents.
Check Digit Verification of cas no
The CAS Registry Mumber 148665-49-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,6,6 and 5 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 148665-49:
(8*1)+(7*4)+(6*8)+(5*6)+(4*6)+(3*5)+(2*4)+(1*9)=170
170 % 10 = 0
So 148665-49-0 is a valid CAS Registry Number.
148665-49-0Relevant academic research and scientific papers
Radatus, Bruno K.
, p. 1281 - 1286 (2011)
A superior process for the commercial production of zidovudine (AZT) has been developed. It was discovered that an AZT-guanidine complex formed when a crude zidovudine solution was treated with guanidine. This readily precipitated from protic solvents resulting in the exclusion of impurities and permitted the development of a superior isolation and purification of AZT.
Preparation and anti-HIV activity of N-3-substituted thymidine nucleoside analogs
Adams, David R.,Perez, Caroline,Maillard, Michel,Florent, Jean-Claude,Evers, Michel,Hénin, Yvette,Litvak, Simon,Litvak, Laura,Monneret, Claude,Grierson, David S.
, p. 1550 - 1558 (2007/10/03)
A series of 22 derivatives of AZT substituted at the N-3 position of the thymine base were prepared and evaluated for anti-HIV activity in cell culture (Lai strain of HIV-1 in CEM-c113 cells). The AZT analogs bearing a N- 3 amino group (7), a hydroxyalkyl
