148669-32-3Relevant academic research and scientific papers
Piperidine compounds which have useful pharmaceutical activity
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, (2008/06/13)
A piperidine derivative having the formula (I): STR1 wherein R1 and R2, which may be the same or different from each other, are (i) a not-substituted phenyl group or a phenyl group substituted by a halogen atom, trifluoromethyl group, a C1-5 alkyl group or a C1-5 alkoxyl group, (ii) a C3-7 cycloalkyl group, (iii) pyridyl group or (iv) thienyl group, R3 is (i) hydrogen atom, (ii) a halogen atom, (iii) a C1-4 alkyl group or (iv) a C1-4 alkoxyl group, R4 is (i) hydrogen atom or (ii) a C1-4 alkyl group. R5 is (i) a not-substituted C1-5 alkyl group or a C1-5 alkyl group substituted by a halogen atom, (ii) phenyl group or (iii) thienyl group and Z is (i) a C1-6 alkylene group, (ii) a C2-6 alkenylene group or (iii) a C3-6 alkynylene group or a pharmacologically acceptable salt thereof. According to the present invention, an anti-allergic agent and a therapeutic agent for ischemic heart disease without toxicity can be provided.
