148671-42-5

Basic information

• Product Name: 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile
• Synonyms: 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile;alpha-(4-Fluorobenzoyl)-4-pyridineacetonitrile
• CAS NO: 148671-42-5
• Molecular Formula: C₁₄H₉FN₂O
• Molecular Weight: 240.2324632
• Mol File: 148671-42-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 429.3±40.0 °C(Predicted)
• Appearance: /
• Density: 1.266±0.06 g/cm3(Predicted)
• PKA: 12.50±0.10(Predicted)
• CAS DataBase Reference: 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile(148671-42-5)
• EPA Substance Registry System: 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile(148671-42-5)

Safety Data

• Hazardous Substances Data: 148671-42-5(Hazardous Substances Data)

Usage

General Description

3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile is a complex chemical compound that contains elements such as fluorine, carbon, hydrogen, and nitrogen. Its molecular formula is C14H9FN2O, which identifies the distinct molecules present and their respective ratios. 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile belongs to the phenylpyridines class that primarily consists of a phenyl group attached to a pyridine ring. The 4-fluorobenzoic acid and 4-pyridinecarboxylic acid fragments in this compound lend it certain properties, possibly including bioactivity. However, specific information about this compound's properties, reactions, or uses is limited and quite specialized, reflecting the need for further exploration in chemical research.

Upstream product

• 66134-67-6 p-fluorobenzoic acid succinimidyl ester 
• 13121-99-8 pyridin-4-ylacetonitrile 

Downstream Products

• 277746-65-3 3-(4-fluorophenyl)-1-methyl-4-(pyridin-4-yl)-1H-pyrazol-5-amine 
• 148671-44-7 3-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-5-amine 
• 277746-28-8 3-(4-fluorophenyl)-5-phenylacetylamino-4-(4-pyridyl)pyrazole 
• 277747-60-1 5-(4-fluorophenyl)-2-methyl-3-phenylacetylamino-4-(4-pyridyl)pyrazole 

Relevant articles and documents

Design and synthesis of 5-[(2-chloro-6-fluorophenyl)acetylamino]-3-(4- fluorophenyl)-4-(4-pyrimidinyl)isoxazole (AKP-001), a novel inhibitor of p38 MAP kinase with reduced side effects based on the antedrug concept

Inhibitors of p38 mitogen-activated protein (MAP) kinase, which are closely involved in the production of inflammatory cytokines, are considered promising curative drugs for chronic inflammatory disorders. However, there is also a growing concern regarding its systemic side effects. To reduce the occurrence of side effects, we have identified a novel p38 MAP kinase inhibitor that shows properties of an antedrug, which imparts its effect solely on the inflammatory site and is metabolically inactivated right after. We have designed isoxazole derivatives through the addition of a fresh interacting fourth site to the structure of the prototypical p38 MAP kinase inhibitor that harbors three point interactive sites. The derivative 26d (AKP-001) shows excellent p38 MAP kinase inhibitory activity and a high selectivity for various kinases. Its rapid metabolism has been confirmed in rats. Moreover, 26d has been shown to be effective in animal models of inflammatory bowel disease.

3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

This invention relates to heterocyclic derivatives useful for inhibiting the production of Interleukin-1 (IL-1) and tumor necrosis factor (TNF) and the like, which can be represented by the following formula: STR1 to a process for their production, to a pharmaceutical composition containing the same and to uses thereof.