148674-74-2Relevant academic research and scientific papers
Synthesis of the Topoisomerase II Inhibitor BE 10988
Moody, Christopher J.,Swann, Elizabeth
, p. 1987 - 1988 (2007/10/02)
The naturally occuring indolequinone BE 10988 1, an inhibitor of topoisomerase II, has been synthesised in an overall yield of 28percent.
Synthesis of the Naturally Occurring Indolequinone BE 10988, an Inhibitor of Topoisomerase II
Moody, Christopher J.,Swann, Elizabeth
, p. 2561 - 2566 (2007/10/02)
A short synthesis (28percent overall yield) of the naturally occuring indolequinone BE 10988 1 is described.The synthesis starts from the 4-benzyloxy-5-methoxyindole and involves, as key steps, the use of chlorosulfonyl isocyanate to introduce the amide side-chain into the indole 3-position, followed by thioamide formation and construction of the thiazole ring using a Hantzsch reaction.
