148693-34-9Relevant academic research and scientific papers
Synthesis of medium-ring lactones via tandem methylenation/Claisen rearrangement of cyclic carbonates
Anderson, Edward A,Davidson, James E.P,Harrison, Justin R,O'Sullivan, Paul T,Burton, Jonathan W,Collins, Ian,Holmes, Andrew B
, p. 1943 - 1971 (2007/10/03)
The conversion of vinyl-substituted 6- and 7-membered cyclic carbonates into 8- and 9-membered medium-ring lactones has been achieved in good yield using dimethyltitanocene in toluene at reflux. The reaction proceeds by initial formation of a ketene acetal which undergoes subsequent in situ Claisen rearrangement to provide the corresponding lactones. The preparation of the cyclic carbonates is carried out under basic conditions and hence this methodology complements our existing selenium-based methodology for the synthesis of medium-ring lactones.
Convergent Synthesis of 2',3'-Dideoxy-3'-methylthio and 2',3'-Dideoxy-3'-mercapto Nucleosides and their Disulfide Analogues - Potential Anti-HIV Agents
Dueholm, Kim L.,Youssef, L. Aly,Joergensen, Per T.,El-Barbary, Ahmed A.,Pedersen, Erik B.,Nielsen, Claus
, p. 37 - 54 (2007/10/02)
The iodide 4(α) or 7 synthesized in three steps from 2-deoxy-D-ribose 1, has been subjected to a number of nucleophilic substitution reactions producing the 3-benzoylthio-, 3-methylthio- and the 3-thiocyanato-2,3-dideoxy-D-erythro-pentofuranosides 8, 13 a
