1487-99-6

Usage

Structure

Seven-membered cyclic ether with two methyl groups attached to the second and seventh carbon atoms

Usage

Building block for organic synthesis, used in the production of various organic molecules and pharmaceuticals

Properties

Antibacterial and antifungal, potential candidate for the development of new antimicrobial agents
Volatile compound with a fruity odor
Used in the flavor and fragrance industry to impart a pleasant scent to various products

Upstream product

• 137053-60-2 4,5-dibromo-1,2-epoxy-1,2-dimethyl-cyclohexane 
• 17351-28-9 1,2-dimethyl-1,4-cyclohexadiene 
• 137053-60-2 trans-4,5-dibromo-1,2-dimethylcyclohexene oxide 

Downstream Products

• 156994-29-5 (3Z,5E,)-octa-3,5-diene-2,7-dione 

Relevant academic research and scientific papers

Direct Observation of an Oxepin from a Bacterial Cytochrome P450-Catalyzed Oxidation

The cytochromes P450 are hemoproteins that catalyze a range of oxidative C-H functionalization reactions, including aliphatic and aromatic hydroxylation. These transformations are important in a range of biological contexts, including biosynthesis and xen

?-Facial stereoselectivity in the Diels-Alder reactions of benzene oxides

The Diels-Alder reactions of N-phenylmaleimide and dimethyl acetylenedicarboxylate with benzene oxide (1,3,5-cyclohexatriene 1,2-oxide, 3) and its more substituted derivatives 1,2-dimethyl-1,3,5-cyclohexatriene 1,2-oxide (7) and 10-oxatricyclodeca-2,4-diene (11) in a kinetic manner gave exclusively products of addition anti to the plane-nonsymmetrical oxygen.The structures of the adducts were determined unequivocally by nuclear Overhauser enhancements in their 1H nuclear magnetic resonance spectra and by X-ray crystallographic methods.The ?-facial stereoselectivity was rationalized in terms of unfavorable orbital interactions, steric hindrance between the dienophile and the syn face of benzene oxide, and ?-donation by the oxygen. Key words: cycloaddition, Diels-Alder, syn-anti, ?-facial stereoselectivity, benzene oxide.