(+/-)-4-HYDROXY-9,9,9,NON-2E-ENAL, also known as 4-hydroxynonenal (4-HNE), is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid. It is a bioactive aldehyde that exhibits various biological activities, including cytotoxicity, growth-inhibiting activity, genotoxicity, and chemotactic activity. 4-HNE is widely used as a marker of lipid peroxidation and has been found to inhibit pro-oxidant-induced Ca2+ release from mitochondria at concentrations of 10-50 μM.
148706-06-3
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Basic information
- Product Name: (+/-)-4-HYDROXY-9,9,9,NON-2E-ENAL
- Synonyms: HNE-D3;(E)-4-HYDROXYNONENAL-D3;4-HNE-D3;(+/-)-4-HYDROXY-9,9,9,NON-2E-ENAL;4-HYDROXY NONENAL-D3;(E)-9,9,9-trideuterio-4-hydroxynon-2-enal
- CAS NO:148706-06-3
- Molecular Formula: C9H13D3O2
- Molecular Weight: 159.24
- EINECS: N/A
- Product Categories: N/A
- Mol File: 148706-06-3.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: (+/-)-4-HYDROXY-9,9,9,NON-2E-ENAL(CAS DataBase Reference)
- NIST Chemistry Reference: (+/-)-4-HYDROXY-9,9,9,NON-2E-ENAL(148706-06-3)
- EPA Substance Registry System: (+/-)-4-HYDROXY-9,9,9,NON-2E-ENAL(148706-06-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 148706-06-3(Hazardous Substances Data)
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148706-06-3 Usage
Uses
Used in Research Applications:(+/-)-4-HYDROXY-9,9,9,NON-2E-ENAL is used as an internal standard for the quantification of 4-HNE by GCor LC-mass spectrometry. This application is crucial for accurate measurement and analysis of 4-HNE levels in various biological samples, which can help in understanding its role in lipid peroxidation and related biological processes.
Used in Pharmaceutical Applications:
(+/-)-4-HYDROXY-9,9,9,NON-2E-ENAL is used as a potential therapeutic agent due to its various biological activities. Its cytotoxic, growth-inhibiting, genotoxic, and chemotactic properties make it a promising candidate for the development of drugs targeting specific diseases and conditions.
Used in Diagnostic Applications:
(+/-)-4-HYDROXY-9,9,9,NON-2E-ENAL is used as a marker of lipid peroxidation, which can be indicative of oxidative stress and cellular damage. Measuring 4-HNE levels in biological samples can help in diagnosing and monitoring the progression of various diseases and conditions associated with oxidative stress.
Used in Antioxidant Research:
(+/-)-4-HYDROXY-9,9,9,NON-2E-ENAL is used in the study of antioxidants and their potential protective effects against oxidative stress. By understanding the interactions between 4-HNE and antioxidants, researchers can develop more effective strategies for combating oxidative stress and its associated health issues.
Used in Mitochondrial Function Research:
(+/-)-4-HYDROXY-9,9,9,NON-2E-ENAL is used in the investigation of mitochondrial function, particularly in relation to Ca2+ release. Its ability to inhibit pro-oxidant-induced Ca2+ release from mitochondria at 10-50 μM can provide valuable insights into mitochondrial dynamics and the role of 4-HNE in cellular processes.
Check Digit Verification of cas no
The CAS Registry Mumber 148706-06-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,7,0 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.Calculate Digit Verification of CAS Registry Number 148706-06:
(8*1)+(7*4)+(6*8)+(5*7)+(4*0)+(3*6)+(2*0)+(1*6)=143
143 % 10 = 3
So 148706-06-3 is a valid CAS Registry Number.
148706-06-3Upstream product
148706-06-3Downstream Products
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(+/-)-4-HYDROXY-9,9,9,NON-2E-ENAL
