148711-53-9

Upstream product

• 123054-36-4 benzhydryl 7β-(2-phenylacetamido)-3-(benzothiazol-2-yl)thio-3-cephem-4-carboxylate 
• 122553-60-0 (6R,7R)-benzhydryl 8-oxo-7-(2-phenylacetamido)-3-(((trifluoromethyl)sulfonyl)oxy)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 2492-26-4 sodium 2-mercaptobenzothiazole 

Downstream Products

• 147380-11-8 (6R,7R)-3-(Benzothiazol-2-ylsulfanyl)-8-oxo-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 153163-95-2 (6R,7R)-7-{2-(5-Amino-[1,2,4]thiadiazol-3-yl)-2-[(Z)-methoxyimino]-acetylamino}-3-(benzothiazol-2-ylsulfanyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Novel cephalosporin derivatives possessing a bicyclic heterocycle at the 3-Position. Part I: Synthesis and biological activities of 3-(benzothiazol-2-yl)thiocephalosporin derivatives, CP0467 and related compounds

A series of cephalosporin derivatives with various bicyclic heterocycles at the C-3 position was synthesized and evaluated for antibacterial activity. Among them CP0467 (3a) showed excellent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) (MIC90=6.25μg/mL), and extremely high affinity for the penicillin binding protein 2' of MRSA (I50=0.49μg/mL). Furthermore, 3a showed a long-acting pharmacokinetic profile in mice (AUC(∞)=482.3μg/h/mL and T(1/2)=1.9h). Copyright (C) 1998 Elsevier Science Ltd.