148743-33-3Relevant articles and documents
Macrocyclic peptidomimetic inhibitors of β-secretase (BACE): First X-ray structure of a macrocyclic peptidomimetic-BACE complex
Rojo, Isabel,Martin, Jose Alfredo,Broughton, Howard,Timm, David,Erickson, Jon,Yang, Hsiu-Chiung,McCarthy, James R.
, p. 191 - 195 (2007/10/03)
The synthesis of novel macrocyclic peptidomimetic inhibitors of the enzyme BACE1 is described. These macrocycles are derived from a hydroxyethylene core structure. Compound 7 was co-crystallized with BACE1 and the X-ray structure of the complex elucidated at 1.6 A resolution. This molecule inhibits the production of the Aβ peptide in HEK293 cells overexpressing APP751sw.