148759-25-5

Basic information

• Product Name: 2-Furancarbonitrile,5-(bromomethyl)-(9CI)
• Synonyms: 2-Furancarbonitrile,5-(bromomethyl)-(9CI)
• CAS NO: 148759-25-5
• Molecular Formula: C₆H₄BrNO
• Molecular Weight: 186.00606
• Product Categories: HALOMETYL
• Mol File: 148759-25-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 244.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.66±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2-Furancarbonitrile,5-(bromomethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Furancarbonitrile,5-(bromomethyl)-(9CI)(148759-25-5)
• EPA Substance Registry System: 2-Furancarbonitrile,5-(bromomethyl)-(9CI)(148759-25-5)

Safety Data

• Hazardous Substances Data: 148759-25-5(Hazardous Substances Data)

Usage

General Description

2-Furancarbonitrile, 5-(bromomethyl)-(9CI) is a chemical compound with the molecular formula C6H4BrNO. It is a derivative of furan, a heterocyclic aromatic compound, and contains a nitrile group and a bromomethyl group. 2-Furancarbonitrile,5-(bromomethyl)-(9CI) may be used in organic synthesis as a reagent for the introduction of the bromomethyl group into various molecules. It may also have potential applications in the pharmaceutical and agrochemical industries due to its reactivity and functional groups. However, it is important to handle this compound with care, as it may pose health and environmental risks due to its toxic and potentially hazardous properties.

Upstream product

• 617-90-3 2-furancarbonitrile 
• 89149-70-2 5-hydroxymethyl-furan-2-carbonitrile 
• 42061-89-2 5-cyano-2-furancarboxaldehyde 

Downstream Products

• 1027236-11-8 C₂₆H₂₇N₅O₅S 
• 203792-32-9 5-aminomethyl-furan-2-carbonitrile; hydrochloride 

Relevant articles and documents

NOVEL INDOLE DERIVATES AS FABP-4 INHIBITORS

The present invention relates to novel compounds (I) wherein R0, R1, R2, R3, R4, R5, R6, R7, R8, A, B, n, X, and Y are as defined in the description and claims; and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament, which acts on the fatty acid binding protein FABP-4. The present invention relates to novel compounds (I) wherein R0, R1, R2, R3, R4, R5, R6, R7, R8, A, B, n, X, and Y are as defined in the description and claims; and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament, which acts on the fatty acid binding protein FABP-4.

Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa

The discovery of a series of non-peptide factor Xa (FXa) inhibitors incorporating 3-(s)-amino-2-pyrrolidinone as a central template is described. After identifying compound 4, improvements in in vitro potency involved modifications of the liphophilic group and optimizing the angle of presentation of the amidine group to the S1 pocket of FXa. These studies ultimately led to compound RPR120844, a potent inhibitor of FXa (K1 = 7 nM) which shows selectivity for FXa over trypsin, thrombin, and several fibrinolytic serine proteinases. RPR120844 is an effective anticoagulant in both the rat model of FeCl2-induced carotid artery thrombosis and the rabbit model of jugular vein thrombus formation.