148759-64-2

Basic information

• Product Name: (S)-(+)-2-Allyl(benzyl)amino-3-methyl-1-butanol
• Synonyms: (S)-(+)-2-Allyl(benzyl)amino-3-methyl-1-butanol
• CAS NO: 148759-64-2
• Molecular Weight: 233.354
• Mol File: 148759-64-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-(+)-2-Allyl(benzyl)amino-3-methyl-1-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-2-Allyl(benzyl)amino-3-methyl-1-butanol(148759-64-2)
• EPA Substance Registry System: (S)-(+)-2-Allyl(benzyl)amino-3-methyl-1-butanol(148759-64-2)

Safety Data

• Hazardous Substances Data: 148759-64-2(Hazardous Substances Data)

Upstream product

• 15363-84-5 (S)-2-(benzylamino)-3-methylbutanoic acid 
• 42807-42-1 N-benzyl-L-valinol 
• 106-95-6 allyl bromide 
• 148759-62-0 (S)-N-Allyl-N-benzylvalinallylester 

Downstream Products

• 221876-48-8 (1R,5R,8S)-(+)-7-Benzyl-8-isopropyl-2-methyl-3-oxa-2,7-diazabicyclo[3.3.0]octan 
• 221876-51-3 (2S,3R,4R)-(2-Isopropyl-3-methylaminopyrrolidin-4-yl)methanol 

Relevant articles and documents

Synthesis of Homochiral 3-Oxa-2,7-diazabicyclooctanes from Amino Acids by Intramolecular 1,3-Dipolar Cycloaddition of Nitrones

N-Allylamino alcohols 9 were prepared from amino acids by various methods.Swern oxidation of 9 afforded aldehydes 11.By reaction of 11 with N-alkylhydroxylamines nitrone intermediates 4 were formed which spontaneously underwent an intramolecular 1,3-dipolar cycloaddition to yield the bicyclic compounds 6.The cycloaddition proceeds diastereoselectively furnishing homochiral compounds 6 from homochiral starting materials.The structure of 6aA was confirmed by X-ray structural analysis. Key Words: Heterobicyclooctanes, homochiral / Amino acids / Nitrones / Cycloadditions, diastereoselective, intramolecular