148763-41-1

Basic information

• Product Name: Methyl N-Boc-piperidine-3-carboxylate
• Synonyms: TERT-BUTYL METHYL PIPERIDINE-1,3-DICARBOXYLATE;METHYL N-BOC-NIPECOTATE;1-TERT-BUTYL 3-METHYL PIPERIDINE-1,3-DICARBOXYLATE;N-Boc-nipecotic acid methyl ester;N-Boc- Piperidine-3-carboxylate;Methyl N-Boc-piperidine-3-carboxylate;REF DUPL: Methyl N-Boc-piperidine-3-carboxylate;N-Boc-piperidine-3-carboxylate Methyl
• CAS NO: 148763-41-1
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.3
• Mol File: 148763-41-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 47.0 to 51.0 °C
• Boiling Point: 307.4 °C at 760 mmHg
• Flash Point: 139.7 °C
• Appearance: Reddish brown viscous liquid
• Density: 1.094 g/cm³
• Vapor Pressure: 0.000726mmHg at 25°C
• Refractive Index: 1.473
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.48±0.40(Predicted)
• CAS DataBase Reference: Methyl N-Boc-piperidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl N-Boc-piperidine-3-carboxylate(148763-41-1)
• EPA Substance Registry System: Methyl N-Boc-piperidine-3-carboxylate(148763-41-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 148763-41-1(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C12H21NO4/c1-12(2,3)17-11(15)13-7-5-6-9(8-13)10(14)16-4/h9H,5-8H2,1-4H3

Upstream product

• 67-56-1 methanol 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 
• 74-88-4 methyl iodide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 89895-55-6 methyl piperidine-3-carboxylate hydrochloride 
• 59-67-6 nicotinic acid 
• 6034-80-6 piperidine-3-carboxylic acid hydrochloride 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 149-73-5 trimethyl orthoformate 
• 50585-89-2 3-methoxycarbonylpiperidine 
• 498-95-3 nipecotic acid 

Downstream Products

• 1158759-06-8 tert-butyl 3-amino-3-methylpiperidine-1-carboxylate 
• 162166-99-6 3-methanesulfonyloxymethyl-piperidine-1-carboxylic acid tert-butyl ester 
• 406212-48-4 tert-butyl 3-(hydroxymethyl)-3-methylpiperidine-1-carboxylate 
• 915925-11-0 (1,3-dimethylpiperidin-3-yl)methanol 
• 914654-74-3 tert-butyl 3-(2-hydroxypropan-2-yl)piperidine-1-carboxylate 
• 252723-21-0 2-(piperidin-3-yl)propan-2-ol 

Relevant articles and documents

Di-oxanipecotic acids as more stable turn motifs than di-nipecotic acids

The folded structures of peptidomimetics containing dimers of oxanipecotic acid (Oxa) in loop segments were characterized and compared with those of the corresponding nipecotic acid (Nip)-based ones. According to structural studies using FT-IR and NMR spectroscopies, di-oxanipecotic acid adopted more stable turn conformations than di-nipecotic acid, and for tetramers, L,(S)-Oxa,(S)-Oxa,L and L,(S)-Oxa,(R)-Oxa,L formed hairpin-like structures but only L,(R)-Nip,(S)-Nip,L promoted the stable folded conformations.

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PDE2 INHIBITORS

The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.

SPIROCYCLIC DERIVATIVES WITH AFFINITY FOR CALCIUM CHANNELS

The invention relates to novel spirocyclic derivatives with affinity for Cav2.2 calcium channels and which are capable of interfering with Cav2.2 calcium channels; to processes for their preparation; to pharmaceutical compositions containing them; and to the use of such compounds in therapy for the treatment of pain.