1488-11-5 Usage
Classification
Synthetic organic compound
Common uses
Building block in the synthesis of pharmaceuticals and other organic compounds
Chemical structure
Pyrrolidinone ring and a phenethyl group
Applications
Medicinal chemistry, drug discovery, precursor in the synthesis of various drugs, chiral auxiliary in stereoselective organic synthesis
Importance
Versatile and significant compound in organic chemistry and drug development
Check Digit Verification of cas no
The CAS Registry Mumber 1488-11-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,8 and 8 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1488-11:
(6*1)+(5*4)+(4*8)+(3*8)+(2*1)+(1*1)=85
85 % 10 = 5
So 1488-11-5 is a valid CAS Registry Number.
1488-11-5Relevant academic research and scientific papers
Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors
Bekkali, Younes,Thomson, David S.,Betageri, Raj,Emmanuel, Michel J.,Hao, Ming-Hong,Hickey, Eugene,Liu, Weimin,Patel, Usha,Ward, Yancey D.,Young, Erick R.R.,Nelson, Richard,Kukulka, Alison,Brown, Maryanne L.,Crane, Kathy,White, Della,Freeman, Dorothy M.,Labadia, Mark E.,Wildeson, Jessi,Spero, Denice M.
, p. 2465 - 2469 (2008/03/11)
The synthesis and in vitro activities of a series of succinyl-nitrile-based inhibitors of Cathepsin S are described. Several members of this class show nanomolar inhibition of the target enzyme as well as cellular potency. The inhibitors displaying the greatest potency contain N-alkyl substituted piperidine and pyrrolidine rings spiro-fused to the α-carbon of the P1 residue.
