148806-97-7

Basic information

• Product Name: N^α-fluoren-9-ylmethoxycarbonyl-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-L-threonine benzyl ester
• Synonyms: N^α-fluoren-9-ylmethoxycarbonyl-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-L-threonine benzyl ester
• CAS NO: 148806-97-7
• Molecular Weight: 761.78
• Mol File: 148806-97-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N^α-fluoren-9-ylmethoxycarbonyl-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-L-threonine benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-fluoren-9-ylmethoxycarbonyl-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-L-threonine benzyl ester(148806-97-7)
• EPA Substance Registry System: N^α-fluoren-9-ylmethoxycarbonyl-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-L-threonine benzyl ester(148806-97-7)

Safety Data

• Hazardous Substances Data: 148806-97-7(Hazardous Substances Data)

Upstream product

• 73724-48-8 N-(fluoren-9-ylmethoxycarbonyl)-L-threonine benzyl ester 
• 13242-53-0 acetobromomannose 
• 83-87-4 D-Mannose pentaacetate 
• 2823-44-1 2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl fluoride 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 65982-19-6 2,3,4,6-tetra-O-acetyl-D-monnopyranosyl chloride 

Downstream Products

• 78609-12-8 3-O-(α-D-mannopyranosyl)-L-threonine 
• 169219-08-3 N^α-(9-fluorenylmethoxycarbonyl)-3-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-L-threonine 

Relevant articles and documents

Synthesis of mannosyl and oligomannosyl threonine building blocks found on the mycobacterium tuberculosis 45 kDa MPT 32 glycoprotein

Mycobacterium tuberculosis secretes a 45 kDa glycoprotein (MPT 32) carrying mannosylated threonine residues. A general strategy was developed to couple peracetylated mannose, α-(1,2)-linked mannobiose or mannotriose to Fmoc-threonine-benzyl ester. Activation of mannosyl acetates or fluorides by borontrifluoride etherate gave the desired Fmoc-glycosyl amino acid building blocks in good yields. The synthesis leads to stable compounds and can easily be scaled up.

Glycosylation of Fmoc amino acids: Preparation of mono- and di-glycosylated derivatives and their incorporation into Arg-Gly-Asp (RGD)-containing glycopeptides

Compounds containing O-glycosidic linkages between carbohydrate species (D-glucopyranose, D-mannopyranose and L-rhamnopyranose) and hydroxy-containing amino acid components (L-threonine, L-serine and L-hydroxyproline) have been synthesized. Significant qu