148811-01-2

Upstream product

• 6014-42-2 L-rhamnose 
• 69992-12-7 (3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-3H-4,5,6-trihydropyran-2-one 
• 20031-16-7 L-Rhamnono-1,4-lactone 
• 22331-81-3 (2R,3R,4R,5S)-2-(hydroxymethyl)-5-methyltetrahydrofuran-3,4-diol 
• 98-59-9 p-toluenesulfonyl chloride 
• 143813-44-9 Trifluoro-methanesulfonic acid (3R,4R,5R,6S)-4,5-dihydroxy-6-methyl-2-oxo-tetrahydro-pyran-3-yl ester 
• 143813-47-2 2-O-trifluoromethanesulphonyl-L-rhamnono-1,4-lactone 
• 143813-45-0 methyl 2,5-anhydro-6-deoxy-L-gluconate 
• 73-34-7 L-rhamnose 

Downstream Products

• 144071-71-6 3R-3-hydroxymuscarine tosylate 

Relevant academic research and scientific papers

3R-hydroxymuscarine from L-rhamnose without protection

The synthesis of the muscarine analogue 3R-3-hydroxymuscarine [(2S,3R,4R,5S)-3,4-dihydroxytetrahydro-N,N,N,5-tetramethyl-2-furanmeth animium tosylate] from L-rhamnose does not require the use of any protecting group.

3-Hydroxymuscarines from L-rhamnose

No protection is necessary for the synthesis of the muscarine analogue 3R-3-hydroxymuscarine from L-rhamnose; a sole silyl ether protecting group is required for the wsynthesis of 3S-3-hydroxymuscarine. Efficient construction of the tetrahydrofuran ring c