1488348-41-9

Upstream product

• 18236-55-0 dichloromethyl(4-methoxyphenyl)silane 
• 3536-96-7 vinylmagnesium chloride 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 24581-82-6 dimethoxy(4-methoxyphenyl)methylsilane 

Downstream Products

• 1488348-42-0 bis(2-hydroxyethyl)(4-methoxyphenyl)methylsilane 
• 1488348-43-1 bis(2-((methylsulfonyl)oxy)ethyl)(4-methoxyphenyl)methylsilane 
• 1488348-37-3 4-(4-methoxyphenyl)-4-methyl-4-silapiperidine hydrochloride 
• 1558028-33-3 C₁₃H₁₈O₂Si 

Relevant academic research and scientific papers

[...] piperidine derivative and its preparation method and use thereof (by machine translation)

The present invention provides a novel structure sila piperidine derivative or a pharmaceutically acceptable salt or solvate thereof, wherein the structure general formula is represented by a formula (I). The present invention further provides a drug composition containing a pharmaceutically effective amount of the sila piperidine derivative or the pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable excipient or additive. The present invention further discloses a synthesis method for the sila piperidine derivative, wherein dichloro-substituted silane is adopted as a starting raw material, and multi-step reactions are integrated and performed in one pot to obtain the high purity pharmaceutical intermediate for preparing the camptothecin sila derivative, wherein the synthesis route is short, the reaction environments, especially the temperature, the pressure and the like, are safe and controlled, and the characteristic of green environmental protection is provided. In addition, the preparation raw materials have the wide sources and are easy to obtain, the preparation method is simple and is easy to operate, the reaction conditions are mild, the synthesized product yield is high, and great industrial application values are provided.

Synthesis of 4-silapiperidine building blocks with N-H groups using the Staudinger reaction

4-Silapiperidines are important skeletons for drug design. In this context, a novel acid-free method for the synthesis of 4-silapiperidine building blocks with N-H groups has been developed, using the Staudinger reaction as the key step. As a proof of principle, the model compounds 13 and 14 were synthesized, starting from Ph2SiCl2 and MeSi(OMe)3, respectively.