1488348-45-3Relevant academic research and scientific papers
Synthesis of 4-silapiperidine building blocks with N-H groups using the Staudinger reaction
Fischer, Markus,Tacke, Reinhold
, p. 7181 - 7185 (2013)
4-Silapiperidines are important skeletons for drug design. In this context, a novel acid-free method for the synthesis of 4-silapiperidine building blocks with N-H groups has been developed, using the Staudinger reaction as the key step. As a proof of principle, the model compounds 13 and 14 were synthesized, starting from Ph2SiCl2 and MeSi(OMe)3, respectively.
