1488363-78-5 Usage
General Description
Adomeglivant is a chemical compound that has been developed as a potential treatment for type 2 diabetes. It acts as an inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which plays a role in regulating the metabolism of glucocorticoids. By inhibiting this enzyme, adomeglivant is thought to reduce the production of cortisol and thereby improve insulin sensitivity and glucose metabolism in individuals with type 2 diabetes. Clinical studies have shown promising results in terms of its ability to lower blood glucose levels and improve other metabolic parameters in patients with diabetes. Adomeglivant is still under investigation and has not yet been approved for clinical use.
Check Digit Verification of cas no
The CAS Registry Mumber 1488363-78-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,8,8,3,6 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1488363-78:
(9*1)+(8*4)+(7*8)+(6*8)+(5*3)+(4*6)+(3*3)+(2*7)+(1*8)=215
215 % 10 = 5
So 1488363-78-5 is a valid CAS Registry Number.
1488363-78-5Relevant articles and documents
Synthesis of C-14 radiolabeled glucagon receptor antagonist and its use in a human mass balance study
Czeskis, Boris A.,Satonin, Darlene K.
, p. 110 - 115 (2017)
The synthesis of the radiolabeled glucagon receptor antagonist 1-[14C] was accomplished based on decarboxylative iodination of acid 2 followed by “reattachment” of 14C carboxylic function. The method allowed a significant reduction i
Efficient synthesis of β-CF3/SCF3-substituted carbonyls via copper-catalyzed electrophilic ring-opening cross-coupling of cyclopropanols
Li, Yong,Ye, Zhishi,Bellman, Tabitha M.,Chi, Teng,Dai, Mingji
, p. 2186 - 2189 (2015/05/13)
The first copper-catalyzed ring-opening electrophilic trifluoromethylation and trifluoromethylthiolation of cyclopropanols to form Csp3-CF3 and Csp3-SCF3 bonds have been realized. These transformations are effic
