1488385-46-1

Basic information

• Product Name: 3-(3-trifluoromethylphenyl)-5-(2-oxopyrrolidin-1-yl)-4,5-dihydroisoxazole
• Synonyms: 3-(3-trifluoromethylphenyl)-5-(2-oxopyrrolidin-1-yl)-4,5-dihydroisoxazole
• CAS NO: 1488385-46-1
• Molecular Weight: 298.265
• Mol File: 1488385-46-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(3-trifluoromethylphenyl)-5-(2-oxopyrrolidin-1-yl)-4,5-dihydroisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-trifluoromethylphenyl)-5-(2-oxopyrrolidin-1-yl)-4,5-dihydroisoxazole(1488385-46-1)
• EPA Substance Registry System: 3-(3-trifluoromethylphenyl)-5-(2-oxopyrrolidin-1-yl)-4,5-dihydroisoxazole(1488385-46-1)

Safety Data

• Hazardous Substances Data: 1488385-46-1(Hazardous Substances Data)

Upstream product

• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 69053-93-6 α-chloro-(3-trifluoromethylbenzaldehyde)oxime 
• 368-83-2 3-(trifluoromethyl)benzaldehyde oxime 

Relevant articles and documents

Facile synthesis of 3-aryl-5-(2-oxopyrrolidin-1-yl)-and 5-(pyridin-4-yl)-4,5-dihydroisoxazoles via 1,3-dipolar cycloaddition under mild conditions

A convenient and efficient synthetic approach for the synthesis of 5-substituted 3-aryl-4,5-dihydroisoxazoles is reported. In the presence of triethylamine, a series of hydroximoyl chlorides were transformed into nitrile oxides, followed by reaction with N-vinyl-2-pyrrolidinone (or 4-vinylpyridine) by a 1,3-dipolar cycloaddition to give novel 4,5-dihydroisoxazole derivatives.