148887-46-1Relevant articles and documents
8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
Buckley, George M,Cooper, Nicola,Dyke, Hazel J,Galleway, Fiona P,Gowers, Lewis,Haughan, Alan F,Kendall, Hannah J,Lowe, Christopher,Maxey, Robert,Montana, John G,Naylor, Robert,Oxford, Janet,Peake, Joanna C,Picken, C Louise,Runcie, Karen A,Sabin, Verity,Sharpe, Andrew,Warneck, Julie B H
, p. 1613 - 1615 (2002)
A series of bicyclic heteroaryl ring systems was considered as a replacement for the 3-cyclopentyloxy-4-methoxyphenyl moiety in rolipram resulting in the discovery of 8-methoxyquinoline-5-carboxamides as potent inhibitors of phosphodiesterase type 4 (PDE4).
Cyclization of lithiated pyridine and quinoline carboxamides: Synthesis of partially saturated pyrrolopyridines and spirocyclic β-lactams
Clayden, Jonathan,Hamilton, Stuart D.,Mohammed, Rukhsana T.
, p. 3673 - 3676 (2007/10/03)
(Chemical Equation Presented) Lithiation of N-benzyl pyridine and quinoline carboxamides α to nitrogen gives anions that undergo intramolecular attack on the pyridine or quinoline ring, either directly or on activation of the ring by N-acylation. The resu
