1489-61-8Relevant academic research and scientific papers
On the regiochemistry of cyclialkylation of regiodefined 4-halo-1-alkenylmetals producing cyclobutenes
Liu, Fang,Negishi, Ei-ichi
, p. 1149 - 1152 (1997)
A combination of recently developed anti-carbometallation of homopropargyl alcohols and cyclialkylation of 4-halo-1-alkenyllithiums of appropriate stereochemistry and regiochemistry provides, for the first time, a regiospecific procedure for the synthesis of regiodefined cyclobutenes presumably via σ-type cyclialkylation, whereas carboalumination of 4-halo-1-alkynylmetals containing Si or Al leads to regioconvergent cyclobutene formation.
