148903-82-6Relevant articles and documents
Synthesis of optically pure 4-cyano and 4-formyl cis-β-lactams via enantiospecific Staudinger reaction
Javaraman,Nandi,Sathe,Deshmukh,Bhawal
, p. 609 - 612 (1993)
Imines 1 and 2 derived from (+)-(1S,2S)-2-amino-1-phenylpropan-1,3-diol on cycloaddition reaction using acid chlorides (or equivalent) 3-6 in the presence of triethylamine furnished stereoselectively cis-β-lactams 7a-f in good yields. The aminols 8b,c on treatment with lead tetraacetate under different reaction conditions gave 4-cyano (9b,c) and 4-formyl (10b,c) β-lactams in high yields.
Application of (+)-(1S,2S)-2-amino-1-phenylpropan-1,3-diol in the formal total synthesis of carbapenems, novel 4-cyano-β-lactams and β-hydroxy aspartates
Jayaraman, Muthusamy,Deshmukh, Rakeep,Bhawal, Baburao M.
, p. 8989 - 9004 (2007/10/03)
The imines derived from (+)-(1S,2S)-2-amino-1-phenylpropan-1,3-diol furnished cis-β-lactams stereoselectively on the Staudinger reaction. These homochiral cis-β-lactams were converted in to cis-β-lactams possessing aminol side chain at C-4. These aminols