148928-15-8

Basic information

• Product Name: FMOC-ISONIPECOTIC ACID
• Synonyms: RARECHEM AR PA 0004;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-PIPERIDINE-4-CARBOXYLIC ACID;N-(9-FLUORENYLMETHOXYCARBONYL)-HEXAHYDROISONICOTINIC ACID;N-(9-FLUORENYLMETHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID;N-(9-FLUORENYLMETHYLOXYCARBONYL)-PIPERIDINE-4-CARBOXYLIC ACID;N-(9-FLUORENYLMETHYLOXYCARBONYL)-ISONIPECOTIC ACID;N-ALPHA-FMOC-PIPERIDINE-4-CARBOXYLIC ACID;BUTTPARK 154\50-71
• CAS NO: 148928-15-8
• Molecular Formula: C₂₁H₂₁NO₄
• Molecular Weight: 351.39574
• EINECS: 2017-001-1
• Product Categories: Amino Acids
• Mol File: 148928-15-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: ~190 °C (dec.)
• Boiling Point: 561.624 °C at 760 mmHg
• Flash Point: 293.46 °C
• Appearance: White/Powder
• Density: 1.293
• Vapor Pressure: 1.89E-13mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: 2-8°C
• PKA: 4.54±0.20(Predicted)
• BRN: 7722550
• CAS DataBase Reference: FMOC-ISONIPECOTIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-ISONIPECOTIC ACID(148928-15-8)
• EPA Substance Registry System: FMOC-ISONIPECOTIC ACID(148928-15-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 148928-15-8(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Fmoc-isonipecotic acid is a useful building block for anti-thrombotic peptide libraries.

InChI:InChI=1/C21H21NO4/c23-20(24)14-9-11-22(12-10-14)21(25)26-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,14,19H,9-13H2,(H,23,24)

Upstream product

• 498-94-2 isonipecotic acid 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 5984-56-5 piperidine-4-carboxylic acid hydrochloride 

Downstream Products

• 661472-77-1 H-Inp-(D-2Nal)-(D-Trp)(Ψ)-Pim 

Relevant articles and documents

Radical-Mediated Activation of Esters with a Copper/Selectfluor System: Synthesis of Bulky Amides and Peptides

Herein, we describe a new approach for the activation of esters via a radical-mediated process enabled by a copper/Selectfluor system. A variety of para-methoxybenzyl esters derived from bulky carboxylic acids and amino acids can be easily converted into the corresponding acyl fluorides, directly used in the one-pot synthesis of amides and peptides. As a proof of concept, this method was applied to the iterative formation of sterically hindered amide bonds.

IMIDAZOTRIAZINONE COMPOUNDS

The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.

Diaminopropionic acid derivatives

A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.