148930-27-2Relevant articles and documents
SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1,5-DIARYL-3-ARYLAMINO-4-CARBOXYMETHYL-2,5-DIHYDRO-2-PYRROLONES AND 1,5-DIARYL-4-CARBOXYMETHYLTETRAHYDROPYRROLE-2,3-DIONES
Gein, V.L.,Popov, A.V.,Kolla, V.E.,Popova, N.A.,Potemkin, K.D.
, p. 343 - 346 (2007/10/02)
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REACTION OF α-KETOGLUTARIC ACID WITH SCHIFF BASES
Gein, V. L.,Popov, A. V.,Andreichikov, Yu. S.
, p. 2291 - 2295 (2007/10/02)
1,5-Diaryl-3-arylamino-4-carboxymethyl-2,5-dihydropyrrol-2-ones were synthesized in the reaction of α-ketoglutaric acid with Schiff bases. Their hydrolysis in concentrated hydrochloric acid results in 1,5-diaryl-3-hydroxy-4-carboxymethyl-2,5-dihydropyrrol-2-ones. These latter are converted into the initial compounds when treated with arylamines. The heating of 1,5-diaryl-4-methoxycarbonyl-2,5-dihydropyrrol-2-ones and their 3-arylamino derivatives above the melting point leads to their decarboxylation, while the treatment with diphenyldiazomethane converts them into the corresponding benzhydryl ethers.