148930-54-5Relevant articles and documents
In Situ Formation of Homogeneous Tellurium Nanodots in Paclitaxel-Loaded MgAl Layered Double Hydroxide Gated Mesoporous Silica Nanoparticles for Synergistic Chemo/PDT/PTT Trimode Combinatorial Therapy
Wen, Jia,Yang, Kui,Li, Hongjuan,Xu, Yongqian,Sun, Shiguo,Ding, Xingcheng,Liu, Fengyu
, p. 2987 - 2996 (2019)
A folic acid (FA) functional drug delivery system (MT?L-PTX?FA) based on in situ formation of tellurium nanodots (Te NDs) in paclitaxel (PTX)-loaded MgAl layered double hydroxide (LDHs) gated mesoporous silica nanoparticles (MSNs) has been designed and fa
Taxane compound glycosylated derivative and preparation method and application thereof
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Paragraph 0096; 0097; 0099, (2018/09/11)
The invention discloses a taxane compound glycosylated derivative and a preparation method and application thereof. Particularly, the invention relates to a kind of taxane compound glycosylated derivatives, of which the solubility is apparently higher tha
Copper-chelating azides for efficient click conjugation reactions in complex media
Bevilacqua, Valentina,King, Mathias,Chaumontet, Manon,Nothisen, Marc,Gabillet, Sandra,Buisson, David,Puente, Celine,Wagner, Alain,Taran, Frederic
supporting information, p. 5872 - 5876 (2014/06/10)
The concept of chelation-assisted copper catalysis was employed for the development of new azides that display unprecedented reactivity in the copper(I)-catalyzed azide-alkyne [3+2] cycloaddition (CuAAC) reaction. Azides that bear strong copper-chelating moieties were synthesized; these functional groups allow the formation of azide copper complexes that react almost instantaneously with alkynes under diluted conditions. Efficient ligation occurred at low concentration and in complex media with only one equivalent of copper, which improves the biocompatibility of the CuAAC reaction. Furthermore, such a click reaction allowed the localization of a bioactive compound inside living cells by fluorescence measurements. Chelating azides were designed to form clickable copper complexes for efficient ligation with alkynes in complex biological media. Among a series of azides that bear nitrogen heterocycles, a bis(triazole) azide allowed ultra-fast click reactions with alkynes within seconds under diluted conditions. The reactivity and stability of this copper complex enabled efficient click reactions inside living cells.