148943-71-9

Upstream product

• 4784-77-4 (E)-1-Bromo-2-butene 
• 7387-69-1 N-benzyl-2,2,2-trifluoroacetamide 
• 504-61-0 (E)-but-2-enol 

Downstream Products

• 107733-62-0 benzyl crotyl amine 
• 119639-84-8 (Z)-N-benzyl-2-buten-1-amine 
• 189438-75-3 C₁₅H₂₆N₃OP 
• 189438-81-1 C₁₅H₂₆N₃OP 
• 189438-85-5 2-methyl-1-phenylbut-3-en-1-amine 

Relevant academic research and scientific papers

Synthesis of N?H Bearing Imidazolidinones and Dihydroimidazolones Using Aza-Heck Cyclizations

The synthesis of unsaturated, unprotected imidazolidinones via an aza-Heck reaction is described. This palladium-catalyzed process allows for the cyclization of N-phenoxy ureas onto pendant alkenes. The reaction has broad functional group tolerance, can b

Aza-[2,3] sigmatropic rearrangement of phosphoramides

The aza-[2,3] sigmatropic rearrangement wits realized by using a phosphoramide group as a stabilization group of the carbanion. Not only (E)-substituted alkene, but also (Z)-, and trisubstituted alkene can be used as substrates.

N,N,N',N'-Tetramethylazodicarboxamide (TMAD), A New Versatile Reagent for Mitsunobu Reaction. Its Application to Synthesis of Secondary Amines

N,N,N',N'-Tetramethylazodicarboxamide, (TMAD), was found to be more versatile in the Mitsunobu reaction than traditional diethyl azodicarboxylate or recently developed 1,1'-(azodicarbonyl)dipiperidine, when used in combination with tributylphosphine in benzene.The usefulness of the reagent was demonstrated by the highly efficient two-step synthesis of benzylcrotylamine from N-benzyltrifluoroacetamide.

1,1′-(azodicarbonyl)dipiperidine-tributylphosphine, a new reagent system for mitsunobu reaction

The 1,1′-(azodicarbonyl)dipiperidine (ADDP)-tributylphosphine (TBP) system was developed as a new institute of the Mitsunobu reagent. The new system activates nitrogen or carbon nucleophiles, known to be innert or poorly reactive with the Mitsunobu reagent, to react with alcohols satisfactorily forming C-N or C-C bonds. The inversion of stereogenic carbinyl carbons was confirmed in the acylaltion reaction of two sec-alcohols.