148983-03-3

Basic information

• Product Name: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-cyclohexylpropanoic acid
• Synonyms: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-cyclohexylpropanoic acid;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(m...;(αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]methylamino]cyclohexanepropanoic acid;(9H-Fluoren-9-yl)MethOxy]Carbonyl N-Me-Cha-OH;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-cyclohexylpropanoic
• CAS NO: 148983-03-3
• Molecular Formula: C₂₅H₂₉NO₄
• Molecular Weight: 407.50206
• Mol File: 148983-03-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 588.5±29.0 °C(Predicted)
• Appearance: /
• Density: 1.198±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.92±0.10(Predicted)
• CAS DataBase Reference: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-cyclohexylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-cyclohexylpropanoic acid(148983-03-3)
• EPA Substance Registry System: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-cyclohexylpropanoic acid(148983-03-3)

Safety Data

• Hazardous Substances Data: 148983-03-3(Hazardous Substances Data)

Usage

General Description

The chemical compound "(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-cyclohexylpropanoic acid" is a complex molecule with a cyclohexylpropanoic acid backbone. It also contains a fluorenyl group, a methylamino group, and a methoxycarbonyl group. The compound is chiral, with an S configuration, and has potential applications in pharmaceuticals or organic synthesis due to its structural complexity and potential reactivity. (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-cyclohexylpropanoic acid may also have potential biological activities or target specific enzymes or receptors due to its unique structure and functional groups.

Upstream product

• 135673-97-1 (S)-3-cyclohexyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid 

Downstream Products

• 148983-05-5 (2S)-α-(methylamino)-N-(1,1-dimethylethyl)cyclohexanepropionamide 
• 148983-04-4 ((S)-1-tert-Butylcarbamoyl-2-cyclohexyl-ethyl)-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester 

Relevant articles and documents

Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators

High blood pressure and consequential cardiovascular diseases are among the top causes of death worldwide. The apelinergic (APJ) system has emerged as a promising target for the treatment of cardiovascular issues, especially prevention of ischemia reperfusion (IR) injury after a heart attack or stroke. However, rapid degradation of the endogenous apelin peptides in vivo limits their use as therapeutic agents. Here, we study the effects of simple homologue substitutions, i.e. incorporation of non-canonical amino acids l-cyclohexylalanine (l-Cha) and l-homoarginine (l-hArg), on the proteolytic stability of pyr-1-apelin-13 and apelin-17 analogues. The modified 13-mers display up to 40 times longer plasma half-life than native apelin-13 and in preliminary in vivo assay show moderate blood pressure-lowering effects. The corresponding apelin-17 analogues show pronounced blood pressure-lowering effects and up to a 340-fold increase in plasma half-life compared to the native apelin-17 isoforms, suggesting their potential use in the design of metabolically stable apelin analogues to prevent IR injury. This journal is

Influence of lipophilicity on the biological activity of cyclic pseudopeptide NK-2 receptor antagonists

A series of cyclic pseudopeptides of the formula cyclo(LeuΨ[CH2NH]Xaa- Gln-Trp-Phe-βAla), where Xaa represents the residue of an α-amino acid, has been synthesized in order to establish the role of the Xaa side chain for tachykinin NK-2 recepto