148993-18-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-4-chlorobenzohydrazide is used as a reactant for the preparation of novel N'-(1-phenylethylidene)benzohydrazides. These compounds have been found to be potent, specific, and reversible inhibitors of LSD1 (Lysine-Specific Demethylase 1), an enzyme that plays a crucial role in various biological processes and has been implicated in the development of certain diseases. By inhibiting LSD1, these benzohydrazides may offer therapeutic benefits in treating conditions related to the dysregulation of this enzyme.
Additionally, 3-Bromo-4-chlorobenzohydrazide can be utilized in the synthesis of other bioactive molecules with potential applications in drug discovery and development. Its unique structural features make it a valuable building block for the creation of new compounds with diverse biological activities.

InChI:InChI=1/C7H6BrClN2O/c8-5-3-4(7(12)11-10)1-2-6(5)9/h1-3H,10H2,(H,11,12)

Upstream product

• 42860-10-6 3-bromo-4-chlorobenzoic acid 
• 107947-17-1 methyl 3-bromo-4-chlorobenzoate 

Downstream Products

• 1423715-14-3 (E)-3-bromo-4-chloro-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)benzohydrazide 

Relevant academic research and scientific papers

SUBSTITUTED CYCLOPROPYL DERIVATIVES

The invention relates to cyclopropyl compounds of formula (I), wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and animals from attack or infestation by invertebrate pests, furthermore, to seed comprising such compounds.

SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS

In one aspect, the invention relates to substituted (E)-N'-(1- phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods fo

High-throughput virtual screening identifies novel N ′-(1- phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors

Lysine specific demethylase 1 (LSD1) plays an important role in regulating histone lysine methylation at residues K4 and K9 on histone H3 and is an attractive therapeutic target in multiple malignancies. Here we report a structure-based virtual screen of